Three‐dimensional numerical simulations of smooth,asymmetrically roughened,and baffled culverts for upstream passage of small‐bodied fish

Traditional box culvert designs lead to development of high velocity zones in the culvert barrel that often impede upstream migration of fish. Herein, three‐dimensional Reynolds‐averaged Navier‐Stokes (RANS)‐ and Large eddy simulation (LES)‐based computational fluid dynamics (CFDs) simulations were performed to compare the effectiveness of smooth, asymmetrically roughened, and corner‐baffled barrels, in creating low‐velocity zones (LVZs) and providing opportunity for upstream passage of small‐bodied fish. The results revealed distinctive benefits provided by the asymmetrically roughened and corner‐baffled barrels relative to the smooth barrel. Cross‐sectional asymmetry, corners, and obstructions are important factors that contribute to the generation of LVZs conducive to fish passage, albeit contiguity of LVZs is required, particularly for weak swimmers. The study demonstrates the adequacy and effectiveness of CFD models to complement traditional laboratory studies in understanding basic mechanisms beneficial to fish passage and to provide insights into future designs.     

水力旋冲钻井工具破岩影响因素模拟及应用

常规的冲击钻井工具不能满足井眼轨迹控制要求、使用寿命有限、缓解脱压不显著等问题,影响了在定向井钻井中的推广应用。建立ø215.9 mm PDC钻头和岩石的有限元模型,分析钻井参数对破岩效率的影响规律,结果表明:冲击频率为17.5 Hz和35 Hz时,破岩效率最优; 破岩效率随钻压增大而增加,而后变化逐渐平缓; 破岩效率随钻头转速增大而增加; 破岩效率随冲击载荷的增加变化平缓。据此研制了新型水力旋冲钻井工具。现场试验表明,该工具符合定向水平井“一趟钻”工艺要求,使机械钻速提高56%,使用寿命达150 h,MWD信号正常。     

铁素体/贝氏体双相钢循环载荷作用下变形行为的模拟研究

为了避免铁素体/贝氏体双相钢管线管在服役过程中的交变载荷作用下引起的塑性损伤，采用有限元模拟方法，建立了Chaboche随动强化模型，研究了铁素体/贝氏体双相钢在循环应变载荷作用下的变形行为。结果显示，在循环应变作用下，应变优先在铁素体中形成累积，并在铁素体、贝氏体界面集中；随应变幅的增大，应变带在铁素体中形成，而贝氏体内累积应变增加不大，两相界面应变差增大。研究表明，铁素体内应变和两相应变差的增加将降低双相钢的塑性变形能力。     

Experimental investigation and numerical simulation analysis of sintered micro-fluidic devices

ABSTRACT

This study investigates the use of numerical simulations to describe the solid-state diffusion of a sintering stage during a metal injection moulding process for micro-fluidic components with 316L stainless steel powders. Finite element (FE) analysis based on a thermo-elasto-viscoplastic model was conducted to describe the densification process of a stainless steel porous component during solid-state sintering. The numerical analyses, which were performed on a 3D micro-structured component with various powder volume loadings to take into account the thermal debinding effect to propose a full debinding sintering simulation, demonstrated that the FE simulation results are in agreement with the experimental ones.     

齐大山铁矿南帮含水构造带探测研究

为解决采空区突发涌水给矿山安全生产带来的安全威胁,以齐大山铁矿为研究对象,以高密度电阻率法含水构造带理论模型的正演模拟研究为基础,运用高密度电阻率法对采场南帮含水构造带的异常范围进行了圈定;运用瞬变电磁法进行了二次探测,并对高密度电阻率法所圈定的异常范围进行了验证。研究表明:含水构造带显示为低阻异常特征,在高密度电阻率法探测成果图中显示的两处低阻异常与含水构造带理论模型的正演模拟结果一致;同时,在瞬变电磁法探测成果图中显示的低阻区域均在高密度电阻率法所圈定的低阻异常范围内,二者相互验证,这两处低阻异常均为含水构造带的地球物理异常特征的显示,表明采用高密度电阻率法和瞬变电磁法组合识别技术可实现对隐伏含水构造带的先导性探测。     

盖子环替换及定点突变提高菜豆环氧化物水解酶对邻甲基苯基缩水甘油醚的催化性能

菜豆环氧化物水解酶1和2（PvEH1、PvEH2）能够动力学拆分外消旋邻甲基苯基缩水甘油醚（rac-oMGE），从而保留(R)-oMGE。基于对PvEH1和PvEH2结构的同源模拟和分析，发现二者分子中的盖子环差异较大，故本文选择盖子环作为研究目标。经融合聚合酶链式反应（FPCR），获得了PvEH2的盖子环区域被PvEH1对应区域替换的杂合酶Pv2Pv1。用全细胞酶E. coli/pv2pv1催化rac-oMGE，当(S)-oMGE刚好水解完全时，产物(S)-3-邻甲苯基-1,2-丙二醇（(S)-oTPD）的ee_p由PvEH2的58.3%提高至75.5%。为进一步提高酶的性质，在Pv2Pv1中选取11个氨基酸位点进行丙氨酸(A)突变，获得最优突变子E. coli/pv2pv1^K176A，活性为E. coli/pv2pv1（4.2U/g）的2.1倍，且当S构型的底物刚好完全水解时，(S)-oTPD的ee_p进一步提高为80.3%。分子对接分析发现，盖子环替换和K176位点突变为A，均使(R)-oMGE环氧环中的C_α更易受到酶中D101位点的攻击。利用E. coli/pv2pv1^K176A催化150mmol/L rac-oMGE水解制备(R)-oMGE（ee_s＞99%）和(S)-oTPD（ee_p=80.4%），二者的产率Y_S和Y_P分别为32.7%和60.1%，时空产率STY_S和STY_P为1.6g/(L·h)和3.3g/(L·h)。本实验为改善EH的催化性质提供了一种有效策略。     

Household endotoxin reduction in the Louisa Environmental Intervention Project for rural childhood asthma

Endotoxin exacerbates asthma. We designed the Louisa Environmental Intervention Project (LEIP) and assessed its effectiveness in reducing household endotoxin and improving asthma symptoms in rural Iowa children. Asthmatic school children (N = 104 from 89 homes) of Louisa and Keokuk counties in Iowa (aged 5-14 years) were recruited and block-randomized to receive extensive (education + professional cleaning) or educational interventions. Environmental sampling collection and respiratory survey administration were done at baseline and during three follow-up visits. Mixed-model analyses were used to assess the effect of the intervention on endotoxin levels and asthma symptoms in the main analysis and of endotoxin reduction on asthma symptoms in exploratory analysis. In the extensive intervention group, dust endotoxin load was significantly reduced in post-intervention visits. The extensive compared with the educational intervention was associated with significantly decreased dust endotoxin load in farm homes and less frequent nighttime asthma symptoms. In exploratory analysis, dust endotoxin load reduction from baseline was associated with lower total asthma symptoms score (Odds ratio: 0.52, 95% confidence interval: 0.29-0.92). In conclusion, the LEIP intervention reduced household dust endotoxin and improved asthma symptoms. However, endotoxin reductions were not sustained post-intervention by residents.     

富水软岩巷道稳定性控制技术研究

富水条件下软岩巷道容易出现大变形及围岩强度大幅度降低等情况,对矿井的生产安全造成极大威胁。为探索富水软岩巷道稳定性控制技术,结合新上海一号煤矿113082工作面运输巷工程实例,采用理论分析方法研究了地下水对巷道围岩及支护结构的影响,提出围岩稳定性控制对策,并对控制方案进行数值模拟验证。针对富水软岩巷道,首先采取导、疏结合的控水措施,减小对原有围岩强度的影响,降低对支护结构的损害;其次采用全断面、多手段联合加固的支护措施,控制围岩变形。工程实际及数值模拟结果表明,对于富水软岩巷道采取以上技术措施,能够有效保证巷道的稳定性。